Three-Dimensional Analysis and Longitudinal Observation for Osteoinductivity Induced by Bone Morphogenetic Protein

• OKEYA Hiroyuki

  Department of Periodontology, Departments of Dental Materials Science,

• ASAKURA Masaki

  Departments of Dental Materials Science,

• HAYASHI Tatsuhide

  Departments of Dental Materials Science,

• UENO Atsuko

  Department of Gerodontology, School of Dentistry, Aichi-Gakuin University, Nagoya, Japan

• ITO Masamitsu

  Department of Periodontology,

• OHNO Yuzo

  Department of Periodontology,

• KAWAI Tatsushi

  Departments of Dental Materials Science,

• NOGUCHI Toshihide

  Department of Periodontology,

Abstract

To obtain the basic information concerning time-sequential development of new bone in the same mouse, micro X-ray CT system was adopted. A cone beam type CT system, for small animals, enabled to extract three-dimensional (3D) images from the time point of bone morphogenetic protein (BMP) implantation through 3–4 weeks postoperatively when usually new ossification could be observed histologically. The results obtained showed the process of new bone formation by BMP from 3D viewpoint. BMP initial contact area to tissue reflected the final shape of new bone, and this observation suggested the technical method to prepare the composite of BMP and scaffold.

Journal

• Journal of Oral Tissue Engineering

  Journal of Oral Tissue Engineering 11 (1), 1-8, 2013

  Japanese Association of Regenerative Dentistry

Keywords

• BMP
• microCT
• osteoinductivity
• Longitudinal observation

Details

• CRID: 1390282680202217984
• NII Article ID: 130004941093
• DOI: 10.11223/jarde.11.1
• ISSN: 18800823
• ISSN: 13489623
• Web Site: https://search.jamas.or.jp/link/ui/2015047034
• Text Lang: en
• Data Source:
  • JaLC
  • CiNii Articles
• Abstract License Flag: Disallowed