出血性ショックに対するliposome‐encapsulated hemoglobinが腸管組織酸素代謝に与える影響  [in Japanese] The Effect of Liposome-Encapsulated Hemoglobin for Intestinal Oxygen Metabolism Following Hemorrhagic Shock  [in Japanese]

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Author(s)

    • 小野寺 謙吾 Onodera Kengo
    • 日本医科大学大学院医学研究科侵襲生体管理学 Department of Emergency and Critical Care Medicine, Nippon Medical School Graduate School of Medicine
    • 増野 智彦 Masuno Tomohiko
    • 日本医科大学大学院医学研究科侵襲生体管理学 Department of Emergency and Critical Care Medicine, Nippon Medical School Graduate School of Medicine
    • 相星 淳一 Aiboshi Junichi
    • 東京医科歯科大学救急災害医学 Department of Acute Critical Care and Disaster Medicine, Tokyo Medical and Dental University
    • 小池 薫 Koike Kaoru
    • 京都大学大学院医学研究科初期診療・救急医学 Department of Primary Care and Emergency Medicine, Kyoto University Graduate School of Medicine
    • 大野 曜吉 Ohno Youkichi
    • 日本医科大学大学院医学研究科法医学 Department of Legal Medicine, Nippon Medical School Graduate School of Medicine
    • 山本 保博 Yamamoto Yasuhiro
    • 日本医科大学大学院医学研究科侵襲生体管理学 Department of Emergency and Critical Care Medicine, Nippon Medical School Graduate School of Medicine

Abstract

<b>Introduction</b>: Splanchnic hypoperfusion is central to the pathogenesis of acute respiratory dysfunction syndrome (ARDS) and multiple organ dysfunction syndrome (MODS) after hemorrhagic shock (HS), which is a leading cause of morality in patients with severe trauma; however, the underlying mechanism remains unclear. The purpose of this study was to examine whether liposome-encapsulated hemoglobin (LEH) improves oxygen metabolism in rat small intestine after HS. <b>Methods</b>: HS was induced by withdrawing blood, and mean arterial pressure was maintained at 40 mmHg for 30 minutes. Rats were then resuscitated with shed blood+2 × shed blood volume in normal saline or LEH (equivalent volume to shed blood)+2 × shed blood volume in normal saline over 120 minutes. The small intestines were harvested at four different time points: before HS, after HS, and at 40 and 120 minutes of resuscitation. The tissue levels of lactate and alanine (μmol/g) were measured with <sup>1</sup>H magnetic resonance spectroscopy. Data are expressed as means ± SD and were compared by means of one-way analysis of variance followed by post hoc analysis using Fisher's protected least significant difference (n=5 in each group). <b>Results</b>: There was no significant difference in hemodynamics between the shed blood and LEH groups. Improvements in intestinal lactate and alanine levels with resuscitation were equivalent in between the shed blood and LEH groups. <b>Conclusion</b>: LEH appears to have a comparable oxygen carrying capacity to blood and may serve as a useful blood substitute.<br>

Journal

  • Nihon Ika Daigaku Igakkai Zasshi

    Nihon Ika Daigaku Igakkai Zasshi 3(2), 89-95, 2007

    The Medical Association of Nippon Medical School

Codes

  • NII Article ID (NAID)
    130004941885
  • NII NACSIS-CAT ID (NCID)
    AA1200910X
  • Text Lang
    JPN
  • Journal Type
    大学紀要
  • ISSN
    1349-8975
  • NDL Article ID
    8809684
  • NDL Source Classification
    ZS7(科学技術--医学)
  • NDL Call No.
    Z74-E436
  • Data Source
    NDL  J-STAGE 
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