Adipose tissue remodeling associated with chronic inflammation and abnormal local immunity in obesity visualized by in vivo molecular imaging method

DOI 参考文献9件
  • Nishimura Satoshi
    Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan Translational Systems Biology and Medicine Initiative, The University of Tokyo, Tokyo, Japan
  • Nagasaki Mika
    Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo, Tokyo, Japan
  • Sugita Junichi
    Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan

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  • Adipose tissue remodeling associated with chronic inflammation and abnormal local immunity in obesity visualized by <I>in vivo</I> molecular imaging method

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Obesity induces adipose tissue inflammation, but little is known about the interrelationships among immune cells. Therefore, to assess the dynamic interplay between multiple cell types in obese adipose, an in vivo visualization technique was developed. In vivo imaging revealed close spatial and temporal interrelationships between angiogenesis and adipogenesis, which were augmented in obese adipose tissue. In addition, increased leukocyte-platelet-endothelial cell interactions were observed in the microcirculation, a hallmark of inflammation. Upregulated expression of adhesion molecules contribute to local activation of inflammatory processes. We also found that large numbers of CD8+ effector T cells infiltrated into the obese adipose tissue, playing major roles in inflammatory macrophage infiltration into obese adipose tissue, induction and maintenance of inflammation, and systemic insulin resistance. Our results demonstrate the power of our imaging technique to analyze multi-cellular interactions in inflammation in vivo and to evaluate new therapeutic interventions.

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