Myeloid-derived suppressor cells in autoimmune diseases

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Author(s)

    • Fujii Wataru
    • Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
    • Ashihara Eishi
    • Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan
    • Kawahito Yutaka
    • Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

Abstract

Myeloid-derived suppressor cells (MDSCs) are of myeloid origin and are able to suppress T cell immune responses. Although MDSCs play important roles in tumor progression by suppressing T cell immune responses and inducing immune tolerance, the roles of MDSCs in autoimmune diseases such as rheumatoid arthritis remain controversial. It is difficult to explain why autoimmune diseases occur despite the recruitment and accumulation of MDSCs, which should suppress the immune response. Here, we review the current knowledge regarding the roles played by MDSCs in animal models of autoimmune disease and in human autoimmune disease. We propose that, at least in some cases, MDSCs prevent further progression of autoimmune disorders and suggest novel therapeutic strategies for autoimmune diseases based on the use of endogenous MDSCs.

Journal

  • Inflammation and Regeneration

    Inflammation and Regeneration 34(3), 124-128, 2014

    The Japanese Society of Inflammation and Regeneration

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