Adiponectin and Healthy Aging in Centenarians

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Author(s)

    • Arai Yasumichi
    • Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine
    • Hirose Nobuyoshi
    • Division of Geriatric Medicine, Department of Internal Medicine, Keio University School of Medicine

Abstract

As the aging population expands rapidly worldwide, it has become increasingly important to identify factors that offer means to promote healthy aging. It is well documented that advancing age is associated with increased body fat and blunted insulin action. Centenarians, who are the best model of successful aging, are a unique exception to this phenomenon. Increasing evidence has documented the preservation of insulin sensitivity and glucose homeostasis along with the very low prevalence of metabolic syndrome, diabetes, and cardiovascular disease among centenarians. We demonstrated that centenarians have a high serum concentration of adiponectin, which was associated with a favorable metabolic phenotype, including higher levels of HDL-C and lipoprotein lipase, and lower levels of hemoglobin A1c, C-reactive protein, and E-selectin concentrations. These observations suggested that high adiponectin concentration may be potentially important for maintaining health and function and could be a target for Anti-Aging Medicine.

Journal

  • ANTI-AGING MEDICINE

    ANTI-AGING MEDICINE 9(1), 1-5, 2012

    Japanese Society of Anti-Aging Medicine

Codes

  • NII Article ID (NAID)
    130004952420
  • Text Lang
    ENG
  • Data Source
    J-STAGE 
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