Adsorption of Salivary-related Proteins on the Surface of Orthodontic Materials Evaluated Using Quartz Crystal Microbalance

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We fabricated quartz crystal microbalance sensors coated with titanium, stainless steel (SS), alumina (Al2O3), and yttria tetragonal zirconia polycrystal (Y-TZP), which were prepared by DC magnetron sputtering. The crystal resonance frequency shift was measured immediately after injection of bovine salivary proteins, namely, bovine serum albumin (BSA) and bovine submaxillary gland mucin (BSM), in phosphate-buffered saline solution. The crystal resonance frequency shift changed depending on the amount of adsorbed protein. Differences in surface topography and roughness were observed among the four sensor types by scanning probe microscopy. X-ray photoelectron spectroscopy indicated that the outer surface of each sensor was a metal oxide. Of the four sensor types, sensors with Al2O3 and Y-TZP coatings exhibited the lowest and highest surface roughness, respectively. Adsorption of BSA and BSM were significantly the lowest and highest on the SS sensor, respectively. This study has revealed the technical basis for distinguishing protein-adsorbing materials of various orthodontic appliances and may contribute to the development of oral rinses that prevent biofilm formation.

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  • Nano Biomedicine

    Nano Biomedicine 2 (2), 114-122, 2010

    ナノ・バイオメディカル学会

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