Antioxidant Promotes Wound Healing on Oral Mucosa in Diabetic Mice

• AOKI Ichita

  Shinsapporo Itta Dental Office Health Sciences University of Hokkaido, School of Dentistry, Division of Oral Medicine and Pathology

• KURASHIGE Yoshihito

  Health Sciences University of Hokkaido, School of Dentistry, Division of Pediatric Dentistry

• NISHIMURA Michiko

  Health Sciences University of Hokkaido, School of Dentistry, Division of Oral Medicine and Pathology

• YAMAZAKI Mami

  Health Sciences University of Hokkaido, School of Dentistry, Division of Oral Medicine and Pathology

• SATO Jun

  Health Sciences University of Hokkaido, School of Dentistry, Division of Oral Medicine and Pathology

• YOSHIDA Kouki

  Health Sciences University of Hokkaido, School of Dentistry, Division of Oral Medicine and Pathology

• SAITOH Masato

  Health Sciences University of Hokkaido, School of Dentistry, Division of Pediatric Dentistry

• ABIKO Yoshihro

  Health Sciences University of Hokkaido, School of Dentistry, Division of Oral Medicine and Pathology

Bibliographic Information

Other Title

• 糖尿病モデルマウスにおける酸化ストレス阻害剤による口腔粘膜創傷治癒の促進
• トウニョウビョウ モデルマウス ニ オケル サンカ ストレス ソガイザイ ニ ヨル コウコウ ネンマク ソウショウ チユ ノ ソクシン

Abstract

Endothelial nitric oxide synthase (eNOS) functions as a preventive for blood vessel impairment. Aberrant expression of eNOS induced by oxidative stress has been found in diabetes. In the present study, we examined whether an antioxidant promoted wound healing on oral mucosa in diabetic mice. We used N-Acetyl-L-Cystein (NAC) as an antioxidant, KK-A^y/TaJcl mice (KK-A^y) and C57BL/6JJcl mice (C57) as mouse model of diabetes and controls. The weights and blood glucose levels were higher in KK-A^y than in C57. Positive reaction for eNOS was faint in blood vessel in KK-A^y. The weight and blood glucose levels were significantly lower in KK-A^y with NAC than those without NAC. NAC induced upregulated expression of eNOS in KK-A^y. The size of wound was significantly smaller in KK-A^y mice with NAC than those without NAC. The results indicate that antioxidant may promote wound healing on oral mucosa in diabetic mice.

Journal

• Journal of Japanese Society of Oral Medicine

  Journal of Japanese Society of Oral Medicine 18 (1), 1-7, 2012

  Japanese Society of Oral Medicine

Keywords

• diabetes
• wound healing
• antioxidant
• eNOS
• NO

Details

• CRID: 1390001205422957824
• NII Article ID: 130004973705
• NII Book ID: AA1257777X
• DOI: 10.6014/jjsom.18.1
• ISSN: 21866155
• ISSN: 21866147
• NDL BIB ID: 024858462
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I024858462
• Web Site: https://www.jstage.jst.go.jp/article/jjsom/18/1/18_1/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2013004898
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed