BONE ENGINEERING-BIOLOGICAL MATERIALS AND BONE MORPHOGENETIC PROTEINS-

• Murata Masaru

  Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido

• Akazawa Toshiyuki

  Hokkaido Industrial Research Institute

• Arisue Makoto

  Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido

Abstract

The biomaterials used in tissue engineering represent a major area of the current study. When the absorption of the biomaterial is too slow, bone formation is inhibited by itself Their bioabsorption for bone engineering should, therefore, coincide with the rate of endogenous bone formation. Bone consists of two major components, collagen and hydroxyapatite, and is a repository of bone morphogenetic proteins (BMPs). In the field of tissue regeneration, pepsin-digested collagen (so-called atelocollagen) is used for tissue engineering as one of the most useful scaffolds. Its excellent biocompatibility, due to its biological characteristics such as absorbable properties and low antigenecity, has elevated collagen to become a primary resource in medical applications. On the other hand, hydroxyapatite is classified as a non-absorbable material and is not harmonized with bone formation and remodeling. Therefore, there is a need for absorbable bioceramics that allow for bone formation and which gradually biodegrade, to be absorbed by the body and replaced by new bone. The BMPs, osteoinductive molecules discovered from bone, are thought to contribute to signal the local mesenchymal cells to proliferate and differentiate to osteoblasts. In this paper, the characteristics of collagen and ceramics, and animal and human studies using BMPs for bone engineering are reviewed.

Journal

• Phosphorus Research Bulletin

  Phosphorus Research Bulletin 17 (0), 51-58, 2004

  Japanese Association of Inorganic Phosphorus Chemistry

Keywords

• Bone
• collagen
• hydroxyapatite
• BMPs
• Tissue engineering

Details

• CRID: 1390282680440403456
• NII Article ID: 130004992494
• DOI: 10.3363/prb1992.17.0_51
• COI: 1:CAS:528:DC%2BD28XotlKks7g%3D
• ISSN: 09184783
• ISSN: http://id.crossref.org/issn/03851605
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed