Characterization of Biomimetics Ceramics with Functionally Graded Structure and Evaluation of Expressing Giant Cells
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- MINAMIDA Yasuhito
- Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido
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- MURATA Masaru
- Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido
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- KUSANO Kaoru
- Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido
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- AKAZAWA Toshiyuki
- Industrial Technology Research Development Hokkaido Research Organization
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- NAGAYASU Hiroki
- Oral and Maxillofacial Surgery, School of Dentistry, Health Sciences University of Hokkaido
Bibliographic Information
- Other Title
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- 傾斜機能構造を有する生体模倣セラミックスの特性と巨細胞出現の評価
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Abstract
We developed a hypothesis that dissoluble absorption and giant cellular absorption are indispensable for bio- ceramics harmonized with bone remodeling. The aim of this study was to investigate the characteristics of porous and modified ceramics and the number of giant cells in subcutaneous tissue. Commercial products of b-tricalcium phosphate (β-TCP (porosity:75%)) were easily modified to functionally graded calcium phosphate ceramics by the partial dissolution–precipitation (PDP) technique, which involved a stirring of 300 rpm in 2% HNO3 solutions (50 cm3) containing Ca2+ and PO43- ions and a supersonic treatment at 120 W and 38 kHz in the same solutions. The dissolution efficiency of porous bTCP block by the supersonic treatment drastically increased with time, depending on the porosity of ceramics. For even dense β-TCP block, enhancement of micro-pores and propagation of nano-cracks were recognized by the supersonic treatment for 7 min.<br/> After the specific PDP technique, Nano-crystals of HAp were successfully precipitated on all over the pore wall surface in the macro- and micro-pores of the ceramics. The PDP-TCP (Partial Dissolution-Precipitation technique-TCP) ceramics were implanted into the back subcutis in 4 week-old Wistar rats. At 3 weeks after the implantation, the PDP-TCP exhibited a significant increase in the number of osteoclast-like giant cells and better affinity for body fluid than original β-TCP products. The results suggested that our PDP treated β-TCP could have a potential for a bioactive scaffold with good giant cell-absorption.
Journal
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- Journal of Japanese Society of Oral Implantology
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Journal of Japanese Society of Oral Implantology 27 (4), 513-520, 2014
Japanese Society of Oral Implantology
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Details 詳細情報について
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- CRID
- 1390001205511195264
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- NII Article ID
- 130005002638
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- ISSN
- 21879117
- 09146695
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed