Self-Assembled Fibrous Nano-Object Generated from Coiled-Coil Polypeptide Diblock Copolymer

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  • Higashi Nobuyuki
    Department of Molecular Chemistry and Biochemistry, Faculty of Science & Engineering, Doshisha University
  • Gondo Yuichi
    Department of Molecular Chemistry and Biochemistry, Faculty of Science & Engineering, Doshisha University
  • Matsumoto Takahiro
    Department of Molecular Chemistry and Biochemistry, Faculty of Science & Engineering, Doshisha University
  • Koga Tomoyuki
    Department of Molecular Chemistry and Biochemistry, Faculty of Science & Engineering, Doshisha University

Abstract

A zwitterionic diblockpolypeptide of poly(L-lysine)-b-poly(L-glutamic acid) having 20 residues as the segment length of both blocks was synthesized and its self-assembling behavior in water was analyzed in detail. It was evidenced that nanofibers based on a coiled-coil-like motif was produced by accompanying with the sigmoidal transition in the secondary structure of blockpolypeptides. Such transition would generate a staggered helix-dimer with sticky-end and it was rearranged to the one-dimensional nanofiber structure.

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