Isolation of mammalian pathogenic bacteria using silkworms

DOI 被引用文献14件 参考文献21件
  • Kaito Chikara
    Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • Usui Kimihito
    Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • Kyuma Tatsuhiko
    Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo
  • Sekimizu Kazuhisa
    Laboratory of Microbiology, Graduate School of Pharmaceutical Sciences, The University of Tokyo

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We developed a method to predict bacterial pathogenicity against mammals by measuring bacterial virulence in silkworms at 37°C, human body temperature. One hundred and twenty-two strains of bacteria were isolated from the intestines of fish and shellfish and tested for their virulence against silkworms. Overnight cultures of 50 strains killed at least 50% of the silkworms when injected into the hemolymph. Of 10 strains that showed the most potent pathogenicity against silkworms, 8 also killed mice within 4 days after injection, including Staphylococcus simiae and Staphylococcus pasteuri, neither of which was previously reported to be pathogenic against mammals. These findings suggest that bacterial pathogenicity against mammals can be predicted based on measurements of silkworm-killing activity.

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  • Drug Discoveries & Therapeutics

    Drug Discoveries & Therapeutics 5 (2), 66-70, 2011

    特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会

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