Availability of serum corticosterone level for quantitative evaluation of morphine withdrawal in mice
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- Ueno Keiko
- Department of Pharmacology, Wakayama Medical University
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- Maeda Takehiko
- Department of Pharmacology, Wakayama Medical University
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- Kiguchi Norikazu
- Department of Pharmacology, Wakayama Medical University
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- Kobayashi Yuka
- Department of Pharmacology, Wakayama Medical University
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- Ozaki Masanobu
- Department of Toxicology, Niigata University of Pharmacy and Applied Life Science
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- Kishioka Shiroh
- Department of Pharmacology, Wakayama Medical University
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Abstract
Physical dependence on morphine is evidenced by the withdrawal syndromes, including body weight loss, which are induced by the discontinuation of morphine exposure or by the treatment with naloxone, an opioid receptor antagonist. The present study was designed to examine whether the elevation of serum corticosterone (SCS) level induced by naloxone-precipitated morphine withdrawal was a useful index to quantify the physical dependence on morphine in mice, which was compared with body weight loss induced by naloxone-precipitated morphine withdrawal. The SCS level was dependent on the dosage and the number of dosing of morphine and challenging dosage of naloxone. Intraplantar injection of formalin, potentially producing inflammatory pain, inhibited both body weight loss and SCS increase induced by naloxone challenge in mice receiving repeated exposure of morphine, indicating that formalin-induced pain attenuated the development of physical dependence on morphine. The magnitude of body weight loss in morphine withdrawal was significantly correlated with the magnitude of naloxone challenge-induced SCS increase. These results suggest that the naloxone-induced increase in SCS level is a quantitative index of the magnitude of physical dependence on morphine in mice.
Journal
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 5 (2), 71-75, 2011
International Research and Cooperation Association for Bio & Socio-Sciences Advancement
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Details 詳細情報について
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- CRID
- 1390282680712798720
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- NII Article ID
- 130005054697
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- ISSN
- 1881784X
- 18817831
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed