<i>In vitro</i> and <i>in vivo</i> anti-MRSA activities of nosokomycins

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Abstract

The anti-methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and <i>S. aureus</i> strains were calculated to be 0.06 to 2.0 μg/mL. They also showed potent inhibitory activity against 54 clinically isolated MRSA strains. Furthermore, nosokomycin A proved effective in the mouse-MRSA infection model.

Journal

  • Drug Discoveries & Therapeutics

    Drug Discoveries & Therapeutics 8(6), 249-254, 2014

    International Research and Cooperation Association for Bio & Socio-Sciences Advancement

Codes

  • NII Article ID (NAID)
    130005054796
  • Text Lang
    ENG
  • ISSN
    1881-7831
  • Data Source
    J-STAGE 
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