<i>In vitro</i> and <i>in vivo</i> anti-MRSA activities of nosokomycins
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- Uchida Ryuji
- Graduate School of Pharmaceutical Sciences, Kitasato University
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- Hanaki Hideaki
- Kitasato Institute for Life Sciences, Kitasato University
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- Matsui Hidenori
- Kitasato Institute for Life Sciences, Kitasato University
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- Hamamoto Hiroshi
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Sekimizu Kazuhisa
- Graduate School of Pharmaceutical Sciences, The University of Tokyo
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- Iwatsuki Masato
- Kitasato Institute for Life Sciences, Kitasato University
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- Kim Yong Pil
- Kitasato Institute for Life Sciences, Kitasato University
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- Tomoda Hiroshi
- Graduate School of Pharmaceutical Sciences, Kitasato University
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抄録
The anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and S. aureus strains were calculated to be 0.06 to 2.0 μg/mL. They also showed potent inhibitory activity against 54 clinically isolated MRSA strains. Furthermore, nosokomycin A proved effective in the mouse-MRSA infection model.
収録刊行物
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- Drug Discoveries & Therapeutics
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Drug Discoveries & Therapeutics 8 (6), 249-254, 2014
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会