Extraction of Xanthones from the Pericarps of <i>Garcinia mangostana</i> Linn. with Supercritical Carbon Dioxide and Ethanol

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  • MISHIMA Kenji
    Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
  • KAWAKAMI Ryo
    Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
  • YOKOTA Haruo
    Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
  • HARADA Takunori
    Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
  • KATO Takafumi
    Department of Chemical Engineering, Faculty of Engineering, Fukuoka University
  • IRIE Keiichi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • MISHIMA Kenichi
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • FUJIWARA Michihiro
    Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
  • MATSUYAMA Kiyoshi
    Department of Biochemistry & Applied Chemistry, Kurume National College of Technology
  • MUSTOFA Salim
    Research Center for Technology of Nuclear Industrial Material, Indonesia Nuclear Energy Agency
  • SALIM Agus
    Faculty of Science and Technology, Syarif Hidayatullah State Islamic University (UIN) Jakarta

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  • Extraction of Xanthones from the Pericarps of Garcinia mangostana Linn. with Supercritical Carbon Dioxide and Ethanol

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Abstract

The extraction of xanthones, such as α-mangostin from the pericarp of mangosteen (Garcinia mangostana Linn.) by supercritical fluid extraction (SFE), for which the solvent was carbon dioxide (CO2), was carried out at 35, 40 and 50 ºC. The extraction pressure was from 10 to 20 MPa. In order to enhance the yield of the extraction, ethanol was added as an entrainer. The yields of xanthones, such as α-mangostin in the extraction were significantly improved, whereas a change in the selectivity of the extract was not observed. We also conducted qualitative and quantitative analyses for xanthones in the extract by HPLC, and analyzed the extraction behavior. The effect of three operating parameters, such as temperature, pressure and the mole fraction of ethanol in a supercritical solution of CO2 on the extraction yield was investigated using the single-factor method.

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