Association between hematological malignancies with decreased red cell A and B antigens and decreased I antigen expression level

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  • SATO Hidehiro
    Division of Transfusion Medicine, Kanazawa University Hospital
  • UTSUMI Maki
    Division of Transfusion Medicine, Kanazawa University Hospital
  • MIYAKAWA Eiko
    Division of Transfusion Medicine, Kanazawa University Hospital
  • YAMAZAKI Hirohito
    Division of Transfusion Medicine, Kanazawa University Hospital
  • YASUE Shizuka
    Division of Transfusion Medicine, Kanazawa University Hospital
  • TAKAMI Akiyoshi
    Division of Transfusion Medicine, Kanazawa University Hospital Department of Hematology, Aichi Medical University Hospital

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Other Title
  • A・B抗原減弱を伴う血液疾患とI抗原減弱の関連性

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Abstract

Decreased red cell A and B antigen expression levels are observed in some hematological malignancies, including acute leukemia. Expression dynamics of I antigens that reside in the subterminal portions of oligosaccharides converted to A, B, and H antigens were analyzed by flow cytometry (FCM) to differentiate from decreased A and B antigen expression levels due to serovars or chimera. We statistically compared I antigen expression level and fluorescence intensity between hematological and nonhematological malignancies with decreased A and B antigen expression levels. Results showed that the I antigen expression level was significantly low for only hematological malignancies. Thus, analysis of I antigen by FCM is more likely to differentiate decreased red cell A and B antigen expression levels due to hematological malignancies from a congenital variant blood type.

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