Phenylboronic Acid-based ¹⁹F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

• NONAKA Hiroshi

  INAMORI Frontier Research Center, Kyushu University

• AN Qi

  INAMORI Frontier Research Center, Kyushu University

• SUGIHARA Fuminori

  Immunology Frontier Research Center, Osaka University

• DOURA Tomohiro

  INAMORI Frontier Research Center, Kyushu University

• TSUCHIYA Akira

  INAMORI Frontier Research Center, Kyushu University

• YOSHIOKA Yoshichika

  Immunology Frontier Research Center, Osaka University

• SANDO Shinsuke

  INAMORI Frontier Research Center, Kyushu University

書誌事項

タイトル別名

• Phenylboronic Acid-based ¹⁹F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

抄録

Herein, we report on a new ¹⁹F MRI probe for the detection and imaging of H₂O₂. Our designed 2-fluorophenylboronic acid-based ¹⁹F probe promptly reacted with H₂O₂ to produce 2-fluorophenol via boronic acid oxidation. The accompanying ¹⁹F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H₂O₂ by ¹⁹F chemical-shift-selective MRI.

収録刊行物

• Analytical Sciences

  Analytical Sciences 31 (4), 331-335, 2015

  社団法人 日本分析化学会

キーワード

• ¹⁹F NMR
• ¹⁹F MRI
• imaging
• molecular probe
• H₂O₂

詳細情報

• CRID: 1390282679236783488
• NII論文ID: 130005061536
• NII書誌ID: AA10500785
• DOI: 10.2116/analsci.31.331
• ISSN: 13482246
• ISSN: 09106340
• NDL書誌ID: 026322079
• PubMed: 25864678
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026322079
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.31.331.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.31.331/fulltext.html
• Web Site: https://www.jstage.jst.go.jp/article/analsci/31/4/31_331/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015386060
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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