Phenylboronic Acid-based ¹⁹F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change (A SPECIAL ISSUE ON MOLECULAR IMAGING FOR BIOANALYSIS) Phenylboronic Acid-based <sup>19</sup>F MRI Probe for the Detection and Imaging of Hydrogen Peroxide Utilizing Its Large Chemical-Shift Change

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Author(s)

Abstract

Herein, we report on a new <sup>19</sup>F MRI probe for the detection and imaging of H<sub>2</sub>O<sub>2</sub>. Our designed 2-fluorophenylboronic acid-based <sup>19</sup>F probe promptly reacted with H<sub>2</sub>O<sub>2</sub> to produce 2-fluorophenol <i>via</i> boronic acid oxidation. The accompanying <sup>19</sup>F chemical-shift change reached 31 ppm under our experimental conditions. Such a large chemical-shift change allowed for the imaging of H<sub>2</sub>O<sub>2</sub> by <sup>19</sup>F chemical-shift-selective MRI.

Journal

  • Analytical Sciences

    Analytical Sciences 31(4), 331-335, 2015

    The Japan Society for Analytical Chemistry

Codes

  • NII Article ID (NAID)
    130005061536
  • NII NACSIS-CAT ID (NCID)
    AA10500785
  • Text Lang
    ENG
  • ISSN
    0910-6340
  • NDL Article ID
    026322079
  • NDL Call No.
    Z54-F482
  • Data Source
    NDL  J-STAGE 
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