Antibody Internalization into Living Cells via Crosslinker-mediated Endocytosis

• Daiki Funamoto

  Graduate School of System Life Sciences, Kyushu University

• Daisuke Asai

  Department of Microbiology, St. Marianna University School of Medicine

• Kazuki Sato

  Department of Environmental Science, Fukuoka Women’s University

• Yoko Yamaguchi

  Department of Environmental Science, Fukuoka Women’s University

• Chan Woo Kim

  Graduate School of System Life Sciences, Kyushu University

• Hikari Sato

  Graduate School of System Life Sciences, Kyushu University

• Elnaz Nakhaei

  Graduate School of System Life Sciences, Kyushu University

• Shingo Matsumoto

  Graduate School of System Life Sciences, Kyushu University

• Takuma Yoshikawa

  Graduate School of System Life Sciences, Kyushu University

• Koichi Sasaki

  Graduate School of System Life Sciences, Kyushu University

• Tatsuhiro Yamamoto

  Institute of Systems, Information Technologies and Nanotechnologies

• Akihiro Kishimura

  Graduate School of System Life Sciences, Kyushu University

• Takeshi Mori

  Graduate School of System Life Sciences, Kyushu University

• Yoshiki Katayama

  Graduate School of System Life Sciences, Kyushu University

抄録

We reported here an alternative strategy of antibody internalization by crosslinker-mediated endocytosis. This crosslinker consists of IgG binding peptide and folic acid as cancer targeting ligands toward the folate receptor, which highly expresses in many cancer cells surface. This crosslinker successfully facilitated antibody internalization into cancer cell by the folate receptor-mediated endocytosis.

収録刊行物

• Chemistry Letters

  Chemistry Letters 44 (4), 468-470, 2015-01-10

  Oxford University Press (OUP)

キーワード

• General Chemistry

詳細情報

• CRID: 1360283694082349824
• NII論文ID: 130005062125
• DOI: 10.1246/cl.141157
• ISSN: 13480715
• ISSN: 03667022
• Web Site: https://academic.oup.com/chemlett/article-pdf/44/4/468/55642596/cl.141157.pdf
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