4-Nitro-3-phenylphenol has both androgenic and anti-androgenic-like effects in rats

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Author(s)

    • TRISOMBOON Jiratthiya TRISOMBOON Jiratthiya
    • Department of Physiology, Faculty of Medicine, Srinakharinwirot University, Bangkok 10110, Thailand|Labortory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan
    • LI ChunMei LI ChunMei
    • College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, P. R. China
    • WATANABE Gen
    • Labortory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan|Department of Basic Veterinary Science, the United Graduate School of Veterinary Sciences, Gifu University, Gifu 501-1193, Japan
    • TAYA Kazuyoshi
    • Labortory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan

Abstract

To investigate the effect of endocrine disruption of 4-nitro-3-phenylphenol (PNMPP) on immature male Wistar-Imamichi rats, the rat pituitary was exposed to PNMPP (10<sup>–5</sup>–10<sup>–9</sup> M) for 24 h with or without gonadotropin-releasing hormone (GnRH) in experiment I. In addition, the Leydig cells (10<sup>–5</sup>–10<sup>–9</sup> M) were exposed to PNMPP for 24 h with or without human chronic gonadotropin (hCG) in experiment II. Our results showed that the PNMPP at 10<sup>–5</sup>–10<sup>–7</sup> M suppressed follicle-stimulating hormone (FSH) and luteinizing hormone (LH) productions from GnRH-stimulated pituitary cells. At the same time, PNMPP 10<sup>–5</sup>–10<sup>–7</sup> M induced an increase in testosterone production from the Leydig cells treated with or without hCG. Based on our results, it can be concluded that that PNMPP might have both androgen agonist action by decreasing FSH and LH production in the pituitary and anti-androgenic action by increasing testosterone production in the Leydig cell.

Journal

  • Journal of Reproduction and Development

    Journal of Reproduction and Development 61(2), 134-137, 2015

    THE SOCIETY FOR REPRODUCTION AND DEVELOPMENT

Codes

  • NII Article ID (NAID)
    130005064912
  • NII NACSIS-CAT ID (NCID)
    AA10936678
  • Text Lang
    ENG
  • ISSN
    0916-8818
  • NDL Article ID
    026342223
  • NDL Call No.
    Z54-H305
  • Data Source
    NDL  J-STAGE 
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