Facile Synthesis of Deuterium-Labelled Geranylgeraniols

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Abstract

<jats:title>Abstract</jats:title> <jats:p>Facile and stereoselective syntheses of three different kinds of deuterium-labelled geranylgeraniol analogs have been achieved. LiAlD4 is used as the deuterium source to ensure high deuterium incorporation. [8,8-d2]- and [9,9-d2]-geranylgeraniols have been prepared for the first time. [10-d]-geranylgeraniol was efficiently prepared with a high degree of deuterium incorporation.</jats:p>

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