Correlation of congenital cytomegalovirus infection in children with unilateral sensorineural hearing loss

• Iwasaki Satoshi

  Department of Hearing Implant Sciences, Shinshu University School of Medicine

• Furutate Sakiko

  Department of Otolaryngology, Shinshu University School of Medicine

• Nishio Shin-ya

  Department of Otolaryngology, Shinshu University School of Medicine

• Yano Takuya

  Department of Otolaryngology, Shinshu University School of Medicine

• Moteki Hideaki

  Department of Hearing Implant Sciences, Shinshu University School of Medicine Department of Otolaryngology, Shinshu University School of Medicine

• Takumi Yutaka

  Department of Hearing Implant Sciences, Shinshu University School of Medicine Department of Otolaryngology, Shinshu University School of Medicine

• Usami Shin-ich

  Department of Otolaryngology, Shinshu University School of Medicine

Bibliographic Information

Other Title

• 一側性難聴児における先天性サイトメガロウイルス感染症の関与

Abstract

Congenital Cytomegalovirus (CMV) infection and mumps infection are major cause of unilateral sensorineural hearing loss (SNHL), but there were few reports showing the frequency of congenital CMV infection in children with unilateral SNHL. The present study investigated the prevalence of congenital CMV infection diagnosed by detection of CMV DNA in dried umbilical cord specimens from children with unilateral SNHL and other causes of unilateral SNHL.<br>This study evaluated 88 children with unilateral SNHL who were referred to the Department of Otolaryngology, Shinshu University School of Medicine from May 2008 to April 2012. DNA was extracted from the dried umbilical cords and CMV DNA was examined by quantitative PCR. CMV DNA was identified in 8 (9.1%) of 88 children with unilateral SNHL. Unilateral severe to profound SNHL and mild to moderate SNHL caused by congenital CMV infection were detected in 9.6% (7/73) and 6.7% (1/15), respectively. Genetic deafness mutations could not be found. In conclusion, congenital CMV infection plays a major role as a cause of unilateral SNHL in children.

Journal

• Otology Japan

  Otology Japan 23 (5), 848-853, 2013

  Japan Otological Society

Keywords

• congenital cytomegalovirus infection
• unilateral sensorineural hearing loss
• dried umbilical cord
• genetic hearing loss

Details

• CRID: 1390282679748609792
• NII Article ID: 130005065211
• DOI: 10.11289/otoljpn.23.848
• ISSN: 18841457
• ISSN: 09172025
• Web Site: https://search.jamas.or.jp/link/ui/2014201766
• Text Lang: ja
• Data Source:
  • JaLC
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed