Molecular mechanisms of angioimmunoblastic T-cell lymphoma

• SAKATA-YANAGIMOTO Mamiko

  Department of Hematology, Faculty of Medicine, University of Tsukuba

Bibliographic Information

Other Title

• 血管免疫芽球性T細胞リンパ腫発症の分子メカニズム
• ケッカン メンエキ ガキュウセイ Tサイボウ リンパシュ ハッショウ ノ ブンシ メカニズム

Abstract

Angioimmunoblastic T-cell lymphoma (AITL) is a distinct subtype of peripheral T-cell lymphoma. The origins of AITL tumor cells were thought to be follicular helper T (TFH) cells based on the common features of these two cell types. Recent findings suggest a multistep model for the development of AITL. The immature blood cells evolve into premalignant (prelymphoma) cells by acquisition of premalignant mutations including TET2 and/or DNMT3A mutations. The premalignant cells finally develop into full-blown tumor cells by accumulation of tumor-specific RHOA mutations. Combinations of premalignant and tumor-specific mutations may induce development of AITL.

Journal

• Rinsho Ketsueki

  Rinsho Ketsueki 56 (3), 246-252, 2015

  The Japanese Society of Hematology

Keywords

• Multistep
• RHOA
• TET2
• AITL

Details

• CRID: 1390001205036622208
• NII Article ID: 130005065344
• NII Book ID: AN00252940
• DOI: 10.11406/rinketsu.56.246
• ISSN: 18820824
• ISSN: 04851439
• NDL BIB ID: 026290062
• PubMed: 25876776
• Web Site: http://id.ndl.go.jp/bib/026290062
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026290062
• Web Site: https://search.jamas.or.jp/link/ui/2015207772
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed