Brief Report : Tissue distribution of indium after repeated intratracheal instillations of indium-tin oxide into the lungs of hamsters
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- Tanaka Akiyo
- Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
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- Hirata Miyuki
- Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
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- Matsumura Nagisa
- Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
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- Kiyohara Yutaka
- Department of Environmental Medicine, Graduate School of Medical Sciences, Kyushu University
書誌事項
- タイトル別名
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- Tissue distribution of indium after repeated intratracheal instillations of indium-tin oxide into the lungs of hamsters
- Tissue distribution of indium after repeated intratracheal instillations of indium‐tin oxide into the lungs of hamsters
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Objectives: The aim of this study was to analyze the tissue distribution of indium after intratracheally instilling indium-tin oxide (ITO) into the lungs of hamsters. Methods: Male Syrian hamsters received an intratracheal dose of 3 mg/kg or 6 mg/kg of ITO particles containing 2.2 mg/kg or 4.5 mg/kg of indium, twice weekly for 8 weeks. In parallel, control hamsters received only an intratracheal dose of distilled water. A subset of hamsters was euthanized periodically throughout the study from 8 up to 78 weeks after the final instillation. The distribution of indium in the lungs, liver, kidneys and spleen, as well as pathological changes in the liver, kidneys, and spleen, was determined. Results: The contents of indium in the lungs in the two ITO groups gradually decreased over the 78-week observation period, with elimination half-lives of approximately 142 weeks for the 3 mg/kg ITO group and 124 weeks for the 6 mg/kg ITO. The indium concentrations in the liver, kidneys, and spleen gradually increased throughout the observation period. Although foci of the lesions were observed histopathologically in the extrapulmonary organs among the two ITO groups, the control group showed similar lesions. Conclusions: The results clearly demonstrate that the clearance of indium from the body is extremely slow after intratracheal instillation in hamsters.(J Occup Health 2015; 57: 189–192)
収録刊行物
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- journal of Occupational Health
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journal of Occupational Health 57 (2), 189-192, 2015
公益社団法人 日本産業衛生学会
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詳細情報
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- CRID
- 1390001204455604608
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- NII論文ID
- 130005066083
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- NII書誌ID
- AA11090645
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- ISSN
- 13489585
- 13419145
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- NDL書誌ID
- 026307131
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- PubMed
- 25735506
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可