Association between epicardial and abdominal visceral adipose tissue with coronary atherosclerosis in patients with a coronary artery calcium of zero

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  • Tsushima Hiroshi
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
  • Yamamoto Hideya
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
  • Kitagawa Toshiro
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
  • Urabe Yoji
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences
  • Tatsugami Fuminari
    Department of Diagnostic Radiology, Hiroshima University Graduate School of Biomedical and Health Sciences
  • Awai Kazuo
    Department of Diagnostic Radiology, Hiroshima University Graduate School of Biomedical and Health Sciences
  • Kihara Yasuki
    Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences

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タイトル別名
  • Association of Epicardial and Abdominal Visceral Adipose Tissue With Coronary Atherosclerosis in Patients With a Coronary Artery Calcium Score of Zero

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Background:We sought to examine whether epicardial and abdominal visceral adipose tissue distribution is associated with coronary atherosclerosis in patients with a coronary artery calcium (CAC) score of zero, assessed by coronary computed tomography angiography (CCTA).Methods and Results:We studied 352 patients with suspected coronary artery disease (mean age 61±11 years, 57% male) with a CAC score of zero who had undergone CCTA. Non-calcified coronary plaques (NCPs) were detected in 102 patients (29%); those causing ≥50% stenosis were found in 15 patients (4%). Patients were divided into 4 groups on the basis of CT-based epicardial adipose tissue (EAT) volume and abdominal visceral adipose tissue (VAT) area using the sex-specific median value. Multivariate analysis showed that the adjusted odds ratios for the presence of NCPs in the high VAT area/low EAT volume group, and the high VAT area/high EAT volume group were 2.80 (95% confidence interval [95% CI]: 1.25–6.35, P=0.01) and 2.68 (95% CI: 1.36–5.45, P=0.004), respectively. Interestingly, the low VAT area/high EAT volume group showed an equivalent adjusted odds ratio of 3.02 (95% CI: 1.33–6.90, P=0.008).Conclusions:EAT volume is eligible as a marker to be evaluated in addition to VAT area in patients with a CAC score of zero. (Circ J 2015; 79: 1084–1091)

収録刊行物

  • Circulation Journal

    Circulation Journal 79 (5), 1084-1091, 2015

    一般社団法人 日本循環器学会

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