LATE BREAKING CLINICAL TRIAL (JCS 2015) : Adaptive Servo-Ventilation Therapy for Patients With Chronic Heart Failure in a Confirmatory, Multicenter, Randomized, Controlled Study

• Momomura Shin-ichi

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

• Seino Yoshihiko

  Department of Cardiology, Cardiovascular Center, Nippon Medical School Chiba Hokusoh Hospital

• Kihara Yasuki

  Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical & Health Sciences

• Adachi Hitoshi

  Division of Cardiology, Gunma Prefectural Cardiovascular Center

• Yasumura Yoshio

  Cardiovascular Division, Osaka National Hospital

• Yokoyama Hiroyuki

  Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center

• Wada Hiroshi

  Division of Cardiovascular Medicine, Saitama Medical Center, Jichi Medical University

• Ise Takayuki

  Department of Cardiovascular Medicine, Institute of Health Biosciences, University of Tokushima Graduate School

• Tanaka Koichi

  Division of Cardiovascular Disease, Miyoshi Central Hospital

• for the SAVIOR-C investigators

• Yoshida Kiyoshi

• Hayashida Akihiro

• Sato Naoki

• Hozumi Takeshi

• Yamashita Hiroshi

• Yamamoto Kazuhiro

• Asanoi Hidetsugu

• Ando Shinichi

• Ito Masaaki

• Inoue Hiroshi

• Ogawa Hisao

• Sata Masataka

• Shimokawa Hiroaki

• Tsutsui Hiroyuki

• Tomoike Hitonobu

• Masuyama Tohru

• Murohara Toyoaki

• Yoshikawa Tsutomu

• Ueshima Kenji

• Momomura S

• Wada H

• Sugawara Y

• Ikeda N

• Tsurumaki Y

• Sata M

• Ise T

• Yagi S

• Tanaka K

• Kobayashi K

• Orita Y

• Taniguchi Y

• Oishi S

• Yokoi K

• Kihara Y

• Oda N

• Hidaka T

• Kajikawa M

• Watanabe Y

• Yokoyama H

• Anzai T

• Nakamura K

• Sugano Y

• Yasuda M

• Fukumitsu M

• Nakayama T

• Kasai T

• Ito M

• Kumagai N

• Sato Y

• Dohi K

• Tanimura M

• Watanabe K

• Haruki N

• Seino Y

• Inami T

• Kato T

• Hiraiwa H

• Kondo T

• Ishihara T

• Yanagihara K

• Hara M

• Jo H

• Ashihara T

• Kubo T

• Muramatsu T

• Nakano S

• Yoshikawa T

• Sasaki S

• Iguch N

• Nagayama M

• Izumi Y

• Adachi H

• Takamatsu H

• Inoue H

• Joho S

• Asanoi H

• Harada D

• Ishise H

• Oshitani K

• Ueno H

• Sunagawa K

• Higo T

• Nishizaka M

• Ogawa H

• Kojima S

• Mizuno K

• Fukuma N

• Kubota Y

• Takahashi H

• Adachi T

• Kimura T

• Hakuno D

• Isobe S

• Akita K

• Masaki N

• Yasu T

• Ohya Y

• Nakagawa Y

• Kondo H

• Shimokawa H

• Nochioka K

• Fukumoto Y

• Murohara T

• Hirashiki A

• Okumura T

• Watarai M

• Koyasu M

• Miura A

• Ishikawa S

• Sakanoue Y

• Kanemori T

• Nakamura Y

• Fujita M

• Iwabuchi M

• Ando K

• Mazaki T

• Kono T

• Itamoto C

• Miura H

• Izumi T

• Yasumura Y

• Hamano G

• Fukuda K

• Kohno T

• Mogi S

• Yamada T

• Kadokami T

• Hosokawa K

• Touyama T

• Okayama H

• Hiasa G

• Tsutsui H

• Yamada S

• Inada T

• Ito H

書誌事項

タイトル別名

• Adaptive Servo-Ventilation Therapy for Patients With Chronic Heart Failure in a Confirmatory, Multicenter, Randomized, Controlled Study

抄録

Background:Adaptive servo-ventilation (ASV) therapy is expected to be novel nonpharmacotherapy with hemodynamic effects on patients with chronic heart failure (CHF), but sufficient evidence has not been obtained.Methods and Results:A 24-week, open-label, randomized, controlled study was performed to confirm the cardiac function-improving effect of ASV therapy on CHF patients. At 39 institutions, 213 outpatients with CHF, whose left ventricular ejection fraction (LVEF) was <40% and who had mild to severe symptoms [New York Heart Association (NYHA) class: ≥II], were enrolled. After excluding 8 patients, 102 and 103 underwent ASV plus guideline-directed medical therapy (GDMT) [ASV group] and GDMT only [control group], respectively. The primary endpoint was LVEF, and the secondary endpoints were HF deterioration, B-type natriuretic peptide (BNP), and clinical composite response (CCR: NYHA class+HF deterioration). LVEF and BNP improved significantly at completion against the baseline values in the 2 groups. However, no significant difference was found between these groups. HF deterioration tended to be suppressed. The ASV group showed a significant improvement in CCR corroborated by significant improvements in NYHA class and ADL against the control group.Conclusions:Under the present study’s conditions, ASV therapy was not superior to GDMT in the cardiac function-improving effect but showed a clinical status-improving effect, thus indicating a given level of clinical benefit. (Circ J 2015; 79: 981–990)

収録刊行物

• Circulation Journal

  Circulation Journal 79 (5), 981-990, 2015

  一般社団法人 日本循環器学会

キーワード

• Adaptive servo-ventilation
• Cardiac function
• Chronic heart failure
• Noninvasive positive pressure ventilation
• Nonpharmacotherapy

詳細情報

• CRID: 1390001205109270528
• NII論文ID: 130005066288
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-15-0221
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 026342542
• PubMed: 25912560
• Web Site: http://id.ndl.go.jp/bib/026342542
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026342542
• Web Site: https://www.jstage.jst.go.jp/article/circj/79/5/79_CJ-15-0221/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015281964
• 本文言語コード: en
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