化学物質のリスク評価における肝肥大の取扱いの基本的考え方  [in Japanese] Basic Principles of Interpretation of Hepatocellular Hypertrophy in Risk Assessment in Japan  [in Japanese]

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Abstract

化学物質で一般的に誘発される肝肥大が生体の適応反応か,毒性(悪影響)かを判断するための科学的な考え方を提示した.外的因子に対して肝細胞の恒常性が維持されている範囲内の肝肥大(肝細胞肥大および肝重量増加)は,適応性変化であり毒性影響ではない.同時に生体の恒常性保持機能の限界を越し,破綻を来した場合の肝細胞肥大は毒性と判断すべきである.具体的には以下の変化を伴う肝肥大は毒性影響の可能性を考える起点になる:(1)肝細胞の壊死と関連する指標や炎症性変化,(2)胆道系の変化,(3)脂質代謝系の変化,(4)色素沈着,(5)タイプや部位の異なる肝細胞肥大の誘発.

This article provided a scientific basis for determining whether liver hypertrophy, a common change in the liver induced by xenobiotics in toxicological studies, is an adaptive or adverse event. To maintain homeostasis in the whole organism, the liver frequently responds to xenobiotic exposure by increasing metabolic capacity via nuclear receptor activation. The resuiting hepatic adaptive responses (hepatocellular hypertrophy and increased relative liver weight) are potentially beneficial to the organism in providing increased capacity to respond to chemical-induced stress. However, excessive responses should be recognized as adverse. Practically, hepatocellular hypertrophy leading to the following alterations should be considered adverse: 1) hepatocellular degeneration/ necrosis, whether or not accompanied with inflammatory reaction, 2) changes indicating damage to biliary tracts, 3) disruption of fat metabolism, 4) pigmentation, 5) deviation from typical localization or morphological features of hypertrophied hepatocytes.

Journal

  • Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi)

    Food Hygiene and Safety Science (Shokuhin Eiseigaku Zasshi) 56(2), 42-48, 2015

    Japanese Society for Food Hygiene and Safety

Codes

  • NII Article ID (NAID)
    130005067294
  • NII NACSIS-CAT ID (NCID)
    AN00117741
  • Text Lang
    JPN
  • Article Type
    journal article
  • ISSN
    0015-6426
  • NDL Article ID
    026410063
  • NDL Call No.
    Z19-364
  • Data Source
    NDL  J-STAGE  JASI 
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