Asymmetric Autocatalysis Triggered by Chiral Crystal of Achiral Ethylenediamine Sulfate
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Achiral ethylenediamine forms chiral structures spontaneously when crystallized as the sulfate salt. By using these chiral crystals of ethylenediamine sulfate (ethylenediammonium sulfate), asymmetric autocatalysis of pyrimidyl alkanol affords a highly enantioenriched product with chirality that is determined by the chirality of the crystals.
- Chemistry Letters
Chemistry Letters 44(5), 688-690, 2015
The Chemical Society of Japan