Therapeutic administration of an ingredient of aged-garlic extracts, <i>S</i>-allyl cysteine resolves liver fibrosis established by carbon tetrachloride in rats

• Kodai Shintaro

  Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Osaka City University

• Takemura Shigekazu

  Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Osaka City University

• Kubo Shoji

  Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Osaka City University

• Azuma Hideki

  Department of Applied and Bioapplied Chemistry, Graduate School of Engineering, Osaka City University

• Minamiyama Yukiko

  Department of Hepato-Biliary-Pancreatic Surgery, Graduate School of Medicine, Osaka City University Food Hygiene and Environmental Health Division of Applied Life Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University

Abstract

S-allyl cysteine (SAC) is the most abundant compound in aged garlic extracts (AGEs). AGE has been reported to ameliorate the oxidative damage implicated in a variety of diseases. However, the effects of SAC have not been established in liver cirrhosis. The aim of this study was to examine the effect of therapeutic administration of SAC in liver cirrhosis by chronic carbon tetrachloride (CCl₄) administration in rats. SAC or other cysteine compounds were administered from 4 weeks when liver fibrosis was confirmed to be in process. CCl₄ administration elevated plasma alanine aminotransferase, plasma lipid peroxidation, liver hydroxyproline, and liver transforming growth factor (TGF)-β at 12 weeks. SAC prevented these changes induced by CCl₄. Furthermore, SAC improved survival in a dose-dependent manner following consecutive CCl₄ administration. The inhibitory mechanisms may be associated with a decrease in the profibrogenic cytokine, TGF-β as well as the antioxidative properties of SAC.

Journal

• Journal of Clinical Biochemistry and Nutrition

  Journal of Clinical Biochemistry and Nutrition 56 (3), 179-185, 2015

  SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Keywords

• aged garlic extracts
• carbon tetrachloride
• cirrhosis
• <i>S</i>-allyl cysteine
• TGF-β

Details

• CRID: 1390001204670732416
• NII Article ID: 130005068184
• DOI: 10.3164/jcbn.14-108
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://search.jamas.or.jp/link/ui/2016045674
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed