The cytotoxicity of organobismuth compounds with certain molecular structures can be diminished by replacing the bismuth atom with an antimony atom in the molecules

• Kohri Kumiko

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Yoshida Eiko

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Yasuike Shuji

  School of Pharmacy, Aichi Gakuin University Division of Bio-organometallics, Research Institute for Science and Technology, Tokyo University of Science

• Fujie Tomoya

  Faculty of Pharmaceutical Sciences, Tokyo University of Science

• Yamamoto Chika

  Division of Bio-organometallics, Research Institute for Science and Technology, Tokyo University of Science Faculty of Pharmaceutical Sciences, Toho University

• Kaji Toshiyuki

  Faculty of Pharmaceutical Sciences, Tokyo University of Science Division of Bio-organometallics, Research Institute for Science and Technology, Tokyo University of Science

抄録

Organic-inorganic hybrid molecules, which are composed of an organic structure and metal(s), are indispensable for synthetic chemical reactions; however, their toxicity has been incompletely understood. In the present study, we discovered two cytotoxic organobismuth compounds whose cytotoxicity diminished upon replacement of the intramolecular bismuth atom with an antimony atom. The intracellular accumulation of the organobismuth compounds was much higher than that of the organoantimony compounds with the corresponding organic structures. We also showed that both the organic structure and bismuth atom are required for certain organobismuth compounds to exert their cytotoxic effect, suggesting that the cytotoxicity of such a compound is a result of an interaction between the organic structure and the bismuth atom. The present data suggest that organobismuth compounds with certain molecular structures exhibit cytotoxicity via an interaction between the molecular structure and the bismuth atom, and this cytotoxicity can be diminished by replacing the bismuth atom with an antimony atom, resulting in lower intracellular accumulation.

収録刊行物

• Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ

  Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃａｌ　Ｓｃｉｅｎｃｅｓ 40 (3), 321-327, 2015

  一般社団法人　日本毒性学会

キーワード

• Organobismuth
• Organoantimony
• Bio-organometallics
• Cytotoxicity

詳細情報

• CRID: 1390282679881872000
• NII論文ID: 130005068415
• NII書誌ID: AN00002808
• DOI: 10.2131/jts.40.321
• ISSN: 18803989
• ISSN: 03881350
• NDL書誌ID: 026522681
• PubMed: 25972193
• Web Site: http://id.ndl.go.jp/bib/026522681
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026522681
• Web Site: https://www.jstage.jst.go.jp/article/jts/40/3/40_321/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016026485
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可