Dengue Hemorrhagic Fever in a Japanese Traveler with Pre-existing Japanese Encephalitis Virus Antibody

DOI 被引用文献2件 参考文献19件 オープンアクセス
  • Sato Rumi
    Department of Internal and Respirology Medicine, Asakura Medical Association Hospital
  • Hamada Nobuyuki
    Department of Infection Control and Prevention, Kurume University School of Medicine
  • Kashiwagi Takahito
    Department of Infection Control and Prevention, Kurume University School of Medicine
  • Imamura Yoshihiro
    Department of Infection Control and Prevention, Kurume University School of Medicine
  • Hara Koyu
    Department of Infection Control and Prevention, Kurume University School of Medicine
  • Nishimura Munetsugu
    Department of Internal and Respirology Medicine, Asakura Medical Association Hospital
  • Kamimura Tomoko
    Department of Internal and Respirology Medicine, Asakura Medical Association Hospital
  • Takasaki Tomohiko
    Laboratory of Neuroviruses, Department of Virology 1, National Institute of Infectious Diseases
  • Watanabe Hiroshi
    Department of Infection Control and Prevention, Kurume University School of Medicine
  • Koga Takeharu
    Department of Internal and Respirology Medicine, Asakura Medical Association Hospital

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抄録

An adult Japanese man who had just returned from Thailand developed dengue hemorrhagic fever (DHF). A primary infection of dengue virus (DENV) was confirmed, specifically DENV serotype 2 (DENV-2), on the basis of the detection of the virus genome, a significant increase in the neutralizing antibody and the isolation of DENV-2. DHF is often observed following a secondary infection from another serotype of dengue virus, particularly in children, but this case was a primary infection of DENV. Japan is a non-endemic country for dengue disease. In fact, only Japanese encephalitis (JE) is known to be a member of the endemic flavivirus family. In this study, IgG antibody against Japanese encephalitis virus (JEV) was detected. JEV belongs to the family of dengue virus and prevails in Japan, particularly Kyushu. Among many risk factors for the occurrence of DHF, a plausible candidate could be a cross-reactive antibody-dependent enhancement (ADE) mechanism caused by JEV antibody. This indicates that most Japanese travelers who living in dengue non-endemic areas, particularly Kyushu, should be aware of the occurrence of DHF.

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