Development of Micro-Flow-Controlled Techniques and Novel Stationary Phases in Capillary Liquid Chromatography

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  • LIM Lee Wah
    Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University

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  • Focusing Review : Development of Micro-Flow-Controlled Techniques and Novel Stationary Phases in Capillary Liquid Chromatography

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Abstract

This focusing review summarizes our recent works on the dissemination of capillary liquid chromatography through various approaches, i.e. simple stepwise-gradient elution system, on-line sample enrichment system, alternate-pumping recycle chromatography system, on-line immobilized-enzyme reactor, development of novel stationary phases, etc. Capillary liquid chromatography saves energy and waste, and it possesses several advantages over the conventional liquid chromatography; however, it has not been much popularized since its appearance and most users still prefer to use conventional liquid chromatography if there is a choice between them. Our research focuses on, but not limited to, developing versatile capillary liquid chromatography systems that are not only environmental-friendly but also user-friendly, and novel stationary phases that could be operated under mixed modes conditions by manipulating the eluent, which are applicable to real samples analyses and will therefore eventually switch the users from “conventional” to “capillary”.

Journal

  • CHROMATOGRAPHY

    CHROMATOGRAPHY 36 (1), 1-12, 2015

    The Society for Chromatographic Sciences

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