オートファジー:メカニズムと膜の起源  [in Japanese] Autophagy: Mechanisms and Membrane Origins  [in Japanese]

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Author(s)

    • Shibutani Shusaku 渋谷 周作
    • 大阪大学大学院生命機能研究科細胞内膜動態研究室/医学系研究科遺伝学教室 Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, /Department of Genetics, Graduate School of Medicine, Osaka University
    • Yoshimori Tamotsu 吉森 保
    • 大阪大学大学院生命機能研究科細胞内膜動態研究室/医学系研究科遺伝学教室 Laboratory of Intracellular Membrane Dynamics, Graduate School of Frontier Biosciences, /Department of Genetics, Graduate School of Medicine, Osaka University

Abstract

Autophagy is an intracellular bulk degradation system that is conserved from yeast to human. When autophagy is induced by stresses such as nutrient starvation, double–membrane vesicles called autophagosomes are formed in the cytoplasm, and the cytosolic components inside the autophagosome are degraded by autophagosome–lysosome fusion. Autophagy is thought to prevent many important diseases such as cancer, neurodegenerative diseases, heart failure, type II diabetes, and pathogen infection, and therefore is an attractive target for clinical applications. In this review, we will discuss Atg proteins that were discovered in 1990's and their functions in relation to autophagosome biogenesis. We will also discuss selective autophagy, which specifically targets unwanted structures and maintains intracellular homeostasis.

Journal

  • MEMBRANE

    MEMBRANE 40(1), 9-20, 2015

    THE MEMBRANE SOCIETY OF JAPAN

Codes

  • NII Article ID (NAID)
    130005069461
  • NII NACSIS-CAT ID (NCID)
    AN0023215X
  • Text Lang
    JPN
  • ISSN
    0385-1036
  • NDL Article ID
    026059081
  • NDL Call No.
    Z18-1127
  • Data Source
    NDL  J-STAGE 
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