Dietary Ribonucleic Acid Suppresses Inflammation of Adipose Tissue and Improves Glucose Intolerance That Is Mediated by Immune Cells in C57BL/6 Mice Fed a High-Fat Diet
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- SAKAI Tohru
- Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- TAKI Tomoyo
- Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- NAKAMOTO Akiko
- Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- TAZAKI Shiho
- Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- ARAKAWA Mai
- Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- NAKAMOTO Mariko
- Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- TSUTSUMI Rie
- Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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- SHUTO Emi
- Department of Public Health and Applied Nutrition, Institute of Health Biosciences, The University of Tokushima Graduate School
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抄録
Recent evidence suggests that immune cells play an important role in differentiation of inflammatory macrophages in adipose tissue, which contributes to systemic chronic inflammation. Dietary ribonucleic acid (RNA) has been shown to modulate immune function. We hypothesized that RNA affects immune cell function in adipose tissue and then improves inflammatory response in adipose tissue. C57/BL6 mice and recombination activating gene-1 (RAG-1) knockout mice on a C57BL/6 mice background were fed a high-fat diet containing 1% RNA for 12 wk. An oral glucose tolerance test was performed. Supplementation of dietary RNA in C57BL/6 mice fed a high-fat diet resulted in a smaller area under the curve (AUC) after oral glucose administration than that for control mice. The mRNA expression levels of inflammation-related cytokines in adipose tissue and serum interleukin-6 levels were reduced by dietary RNA supplementation. Interestingly, reduction of the AUC value by RNA supplementation was abolished in T and B cell-deficient RAG-1 knockout mice. These results indicate that RNA improves inflammation in adipose tissue and reduces the AUC value following oral glucose administration in a T and B cell-dependent manner.
収録刊行物
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- Journal of Nutritional Science and Vitaminology
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Journal of Nutritional Science and Vitaminology 61 (1), 73-78, 2015
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詳細情報 詳細情報について
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- CRID
- 1390282681302019328
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- NII論文ID
- 130005070836
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- NII書誌ID
- AA00703822
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- ISSN
- 18817742
- 03014800
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- NDL書誌ID
- 026193509
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- PubMed
- 25994141
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可