Glutamate as a Potential Protective Drug in the Gastrointestinal Mucosa

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  • Amagase Kikuko
    Department of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University
  • Nakamura Eiji
    Frontier Research Labs., Institute for Innovation, Ajinomoto Co., Inc.
  • Kato Shinichi
    Department of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University
  • Takeuchi Koji
    Department of Pharmacology and Experimental Therapeutics, Division of Pathological Sciences, Kyoto Pharmaceutical University General Incorporated Association, Kyoto Research Center for Gastrointestinal Diseases

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Other Title
  • グルタミン酸の消化管粘膜保護薬としての可能性
  • Symposium Review グルタミン酸の消化管粘膜保護薬としての可能性
  • Symposium Review グルタミンサン ノ ショウカカン ネンマク ホゴヤク ト シテ ノ カノウセイ

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Abstract

  Monosodium glutamate (MSG) is known to provide the umami taste in the food. We have recently reported that glutamate has the potential to protect the small intestine against non-steroidal anti-inflammatory drugs (NSAIDs)-induced lesions in rats. In this paper, we examined this protective effect using sodium loxoprofen, one of the NSAIDs frequently used in Asian countries, to determine whether MSG accelerates the healing of loxoprofen-induced small intestinal lesions in rats. Loxoprofen at 60 mg/kg caused hemorrhagic lesions in the small intestine, mainly in the jejunum and ileum. These lesions spontaneously healed within 7 days, but this healing process was delayed by repeated administration of loxoprofen at low doses (10, 30 mg/kg) for 5 d after lesion induction. The healing-impairment action of loxoprofen was accompanied by the down-regulation of vascular endothelium-derived growth factor (VEGF) expression and an angiogenic response. The impaired healing caused by loxoprofen was significantly restored by co-treatment with a diet containing 5% MSG for 5 d, accompanied by the enhancement of VEGF expression and angiogenesis. We suggest that daily intake of MSG not only protects the small intestine against NSAIDs-induced damage but also exerts healing-promoting effects on these lesions.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 135 (6), 779-782, 2015-06-01

    The Pharmaceutical Society of Japan

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