Anethole inhibits growth of recently emerged multidrug resistant toxigenic <i>Vibrio cholerae</i> O1 El Tor variant strains <i>in vitro</i>
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To search natural compounds having inhibitory effect on bacterial growth is important, particularly in view of growing multidrug resistant (MDR) strains of bacterial pathogens. Like other bacterial pathogens, MDR <i>Vibrio cholerae,</i> the causative agent of diarrheal disease cholera, is becoming a great concern. As an approach of searching new antimicrobial agents, here, we show that anethole, a well-studied natural component of sweet fennel and star anise seeds, could potentially inhibit the growth of MDR O1 El Tor biotype, the ongoing 7th cholera pandemic variant strains of toxigenic <i>V. cholerae</i>. The minimum inhibitory concentration (MIC) of anethole against diverse O1 El Tor biotype strains is evaluated as 200 <i>µ</i>g/m<i>l</i>. Moreover, the effect of anethole is bactericidal and exerts rapid-killing action on <i>V. cholerae</i> cells. This study is the first report which demonstrates that anethole, purified from natural compound, is a potent inhibitor of growth of toxigenic <i>V. cholerae</i>. Our data suggest that anethole could be a potential antimicrobial drug candidate, particularly against MDR <i>V. cholerae</i> mediated infections.
- Journal of Veterinary Medical Science
Journal of Veterinary Medical Science 77(5), 535-540, 2015
JAPANESE SOCIETY OF VETERINARY SCIENCE