Fibronectin Matrix Assembly and Its Significant Role in Cancer Progression and Treatment

• Yoneda Atsuko

  Laboratory of Genome and Biosignals, Tokyo University of Pharmacy and Life Sciences

Bibliographic Information

Other Title

• フィブロネクチンマトリックス形成とがんにおけるその重要性

Abstract

Recently, the significant role of the extracellular matrix (ECM) in tumor progression has garnered great attention in biomedical research. Fibronectin (FN), an essential ECM glycoprotein in development and wound healing, is deregulated in various diseases, such as cancer and fibrosis. Alterations in FN fibril organization can affect ECM organization, cancer cell migration and growth, and tumor angiogenesis. This minireview discusses the recent advances in studies of the molecular mechanisms underlying FN matrix assembly, provides an overview of the role of FN matrix assembly in cancer progression, and highlights the potential for FN matrices as therapeutic targets or tools for cancer treatment.

Journal

• Trends in Glycoscience and Glycotechnology

  Trends in Glycoscience and Glycotechnology 27 (155), 89-98, 2015

  FCCA(Forum: Carbohydrates Coming of Age)

Keywords

• fibronectin matrix assembly
• integrin
• actin cytoskeleton
• contractile force
• cancer

Details

• CRID: 1390282679345201152
• NII Article ID: 130005072347
• NII Book ID: AA10995236
• DOI: 10.4052/tigg.1421.1
• ISSN: 18832113
• ISSN: 09157352
• NDL BIB ID: 026700320
• Web Site: http://id.ndl.go.jp/bib/026700320
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026700320
• Web Site: https://search.jamas.or.jp/link/ui/2015357436
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed