多能性幹細胞のT細胞研究への応用  [in Japanese] Pluripotent stem cells as a source for T cell research and clinical application  [in Japanese]

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Author(s)

    • 上田 樹 UEDA Tatsuki
    • 京都大学iPS細胞研究所増殖分化機構研究部門|京都大学医学部消化器内科 Department of Cell Growth and Development, Center for iPS Cell Reserch and Application (CiRA), Kyoto University|Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine
    • 金子 新 KANEKO Shin
    • 京都大学iPS細胞研究所増殖分化機構研究部門 Department of Cell Growth and Development, Center for iPS Cell Reserch and Application (CiRA), Kyoto University

Abstract

抗PD-1抗体などを用いたT細胞の賦活化による腫瘍免疫療法が最近注目されており,T細胞を用いた免疫細胞療法においても腫瘍浸潤リンパ球やTCR/CAR(Chimeric Antigen Receptor)導入などによる方法が徐々に成果をみせはじめている.免疫細胞療法の奏功において分化のあまりすすんでいないメモリーフェノタイプの細胞が重要であることが指摘される一方で,患者体内に存在する抗原特異的T細胞は細胞疲弊による機能低下やアポトーシス感受性の増加をきたしているという問題がある.今回我々は細胞疲弊を解除しT細胞を"若返らせる"方法としてiPS細胞を介したT細胞再生に成功した.本稿ではこの新しい技術を紹介するとともに,この技術を用いた免疫細胞治療の今後の可能性について述べたい.

Recently, promising clinical outcomes of cancer immunotherapy including administration of an anti PD-1 antibody targeting for T cell reactivation has gained particular attention worldwide. Adoptive cell therapy with tumor infiltrating lymphocytes and TCR/CAR (Chimeric Antigen Receptor) transgenic T cells are also under development. Although it has become clearer that the efficacy of adoptive cell therapy correlate with the quality of infusing T cells, antigen specific T cells in patients with chronic infection and cancer have been exhausted. We have succeeded to generate rejuvenated antigen specific T cells by reprogramming to pluripotency and differentiation. In this article, we introduce fundamentals of this technology and describe its potential for adoptive cell therapy in the future.

Journal

  • Japanese Journal of Clinical Immunology

    Japanese Journal of Clinical Immunology 38(2), 101-108, 2015

    The Japan Society for Clinical Immunology

Codes

  • NII Article ID (NAID)
    130005072692
  • NII NACSIS-CAT ID (NCID)
    AN00357971
  • Text Lang
    JPN
  • Article Type
    journal article
  • ISSN
    0911-4300
  • Data Source
    IR  J-STAGE 
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