HIV-negative Primary Bone Marrow Hodgkin Lymphoma Manifesting with a High Fever Associated with Hemophagocytosis as the Initial Symptom: A Case Report and Review of the Previous Literature

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Author(s)

    • Morita Yasuyoshi
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Miyatake Junichi
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Tatsumi Yoichi
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Ashida Takashi
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Kimura Masatomo
    • Department of Pathology, Kinki University Faculty of Medicine, Japan
    • Ito Masafumi
    • Department of Pathology, Japanese Red Cross Nagoya First Hospital, Japan
    • Matsumura Itaru
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Emoto Masakatsu
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Serizawa Kentaro
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Rai Shinya
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Hirase Chikara
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Kanai Yoshitaka
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Ohyama Yasuyo
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Shiga Toshihiko
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan
    • Tanaka Hirokazu
    • Division of Hematology and Rheumatology, Department of Internal Medicine, Kinki University Faculty of Medicine, Japan

Abstract

A 68-year-old man was referred to our hospital due to a high fever and pancytopenia. Neither tumors nor infectious lesions were detected. Hemophagocytosis was observed on the bone marrow (BM) smear, although without abnormal cells. Prednisolone therapy was ineffective for the patient's high fever. Later on, we obtained the results of a BM biopsy indicating the presence of infiltration of atypical Reed-Sternberg cells, leading to a diagnosis of HIV-negative primary bone marrow Hodgkin lymphoma (PBMHL). However, the patient died of multiple organ failure before receiving chemotherapy. As the clinical course of PBMHL is rapid, physicians must keep in mind its possibility in similar cases.<br>

Journal

  • Internal Medicine

    Internal Medicine 54(11), 1393-1396, 2015

    The Japanese Society of Internal Medicine

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