Association Between Endothelial Function (Assessed on Reactive Hyperemia Peripheral Arterial Tonometry) and Obstructive Sleep Apnea, Visceral Fat Accumulation, and Serum Adiponectin

• Azuma Masanori

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Chihara Yuichi

  Department of Respiratory Medicine, Otsu Red Cross Hospital

• Yoshimura Chikara

  Sleep Apnea Center, Kyusyu University Hospital

• Murase Kimihiko

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Hamada Satoshi

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Tachikawa Ryo

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Matsumoto Takeshi

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Inouchi Morito

  Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University

• Tanizawa Kiminobu

  Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University

• Handa Tomohiro

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Oga Toru

  Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University

• Mishima Michiaki

  Department of Respiratory Medicine, Graduate School of Medicine, Kyoto University

• Chin Kazuo

  Respiratory Care and Sleep Control Medicine, Graduate School of Medicine, Kyoto University

抄録

Background:Visceral obesity, low adiponectin, and severe obstructive sleep apnea (OSA) are associated with cardiovascular diseases, but the interactions among these factors on endothelial dysfunction are not well known.Methods and Results:Endothelial function in 133 patients after polysomnography was evaluated as reactive hyperemia index (RHI) on reactive hyperemia peripheral arterial tonometry. Visceral obesity was defined as visceral fat area ≥100 cm²on computed tomography. RHI was significantly correlated with apnea hypopnea index (AHI), visceral fat area, and serum adiponectin (r=–0.24, P=0.0055, r=–0.19, P=0.031, and r=0.20, P=0.019, respectively). RHI in patients with visceral obesity was significantly decreased in the presence of severe OSA (AHI ≥30; P=0.042). On multivariate regression analysis, only severe OSA remained as an independent predictive factor of RHI (P=0.024, R²=5.4%). RHI in patients with severe OSA (n=44) was significantly improved after 3 months of continuous positive airway pressure (CPAP) treatment (1.78±0.40 before CPAP vs. 2.00±0.53 after CPAP, P=0.013), similarly to those with AHI <30 (P=0.45).Conclusions:Severe OSA, but not visceral fat area or serum adiponectin, was independently associated with endothelial function according to RHI. In addition, impaired endothelial function was reversible following 3 months of CPAP treatment. (Circ J 2015; 79: 1381–1389)

収録刊行物

• Circulation Journal

  Circulation Journal 79 (6), 1381-1389, 2015

  一般社団法人 日本循環器学会

キーワード

• Adiponectin
• Continuous positive airway pressure
• Endothelial function
• Obstructive sleep apnea
• Visceral obesity

詳細情報

• CRID: 1390282680082965248
• NII論文ID: 130005073141
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-14-1303
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 026398946
• PubMed: 25808226
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026398946
• Web Site: https://www.jstage.jst.go.jp/article/circj/79/6/79_CJ-14-1303/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2015333552
• 本文言語コード: en
• データソース種別:
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  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
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