Effects of Dietary Calcium Supplementation on Bone Metabolism, Kidney Mineral Concentrations, and Kidney Function in Rats Fed a High-Phosphorus Diet

• KATSUMATA Shinichi

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• MATSUZAKI Hiroshi

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

• UEHARA Mariko

  Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of Agriculture

• SUZUKI Kazuharu

  Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture

Abstract

We investigated the effects of dietary calcium (Ca) supplementation on bone metabolism, kidney mineral concentrations, and kidney function in rats fed a high-phosphorus (P) diet. Wistar strain rats were randomly divided into 4 dietary groups and fed their respective diets for 21 d: a diet containing 0.3% P and 0.5% Ca (C), a diet containing 1.5% P and 0.5% Ca (HP), a diet containing 0.3% P and 1.0% Ca (HCa), or a diet containing 1.5% P and 1.0% Ca (HPCa). Compared to the C group, the high-P diet increased serum parathyroid hormone concentration, markers of bone turnover, receptor activator of NF-κB ligand mRNA expression of the femur, kidney Ca and P concentrations, urinary N-acetyl-β-D-glucosaminidase activity, and urinary β₂-microglobulin excretion, and decreased bone mineral content and bone mineral density of the femur and tibia. Dietary Ca supplementation improved the parameters of bone metabolism and kidney function in rats fed the high-P diet, while there were no significant differences in kidney Ca or P concentrations between the HP and HPCa groups. These results suggest that dietary Ca supplementation prevented the bone loss and decline in kidney function induced by a high-P diet, whereas dietary Ca supplementation did not affect kidney mineral concentrations in rats fed the high-P diet.

Journal

• Journal of Nutritional Science and Vitaminology

  Journal of Nutritional Science and Vitaminology 61 (2), 195-200, 2015

  Center for Academic Publications Japan

Keywords

• high-phosphorus diet
• dietary calcium supplementation
• bone metabolism
• kidney mineral concentration
• kidney function

Details

• CRID: 1390001206323980416
• NII Article ID: 130005074120
• NII Book ID: AA00703822
• DOI: 10.3177/jnsv.61.195
• ISSN: 18817742
• ISSN: 03014800
• NDL BIB ID: 026378993
• PubMed: 26052152
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026378993
• Web Site: https://search.jamas.or.jp/link/ui/2016026169
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed