Vitamin A Deficiency Impairs Induction of Oral Tolerance in Mice

• NAKAMOTO Akiko

  Department of Public Health and Applied Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School

• SHUTO Emi

  Department of Public Health and Applied Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School

• TSUTSUMI Rie

  Department of Public Health and Applied Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School

• NAKAMOTO Mariko

  Department of Public Health and Applied Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School

• NII Yoshitaka

  Food and Biotechnology Division, Tokushima Prefectural Industrial Technology Center

• SAKAI Tohru

  Department of Public Health and Applied Nutrition, Institution of Health Bioscience, The University of Tokushima Graduate School

抄録

Oral tolerance is a phenomenon of induction of systemic unresponsiveness to antigens ingested by the oral route and loss of immune response. Studies have shown the importance of vitamin A in oral tolerance in vitro but not in an in vivo experimental model. Therefore, we carried out experiments to determine how vitamin A deficiency affects tolerance induction and the ability of mesenteric lymph node (MLN) CD11c⁺ cells to induce regulatory T cells (Tregs). Immunological tolerance was induced by oral ovalbumin (OVA) administration in vitamin A-sufficient mice. OVA-specific antibody and cytokine production were significantly reduced. On the other hand, in vitamin A-deficient mice, both OVA-specific antibody and cytokine production were not suppressed by oral OVA administration. Regarding induction of Tregs, the conversion rate of Foxp3⁺ cells from naïve CD4⁺ cell by CD11c⁺ cells was decreased in vitamin A-deficient mice. Our study indicates that vitamin A deficiency causes the breakdown of oral tolerance in vivo.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ 61 (2), 147-153, 2015

  一般財団法人 学会誌刊行センター

キーワード

• oral tolerance
• vitamin A deficiency
• regulatory T cells
• CD11c⁺ cells
• antibody

詳細情報

• CRID: 1390001206323984000
• NII論文ID: 130005074125
• NII書誌ID: AA00703822
• DOI: 10.3177/jnsv.61.147
• ISSN: 18817742
• ISSN: 03014800
• NDL書誌ID: 026378882
• PubMed: 26052145
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026378882
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可