<i>Staphylococcus epidermidis</i> Adhesion to Prosthetic Biomaterials: An <i>In Vitro</i> Study

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  • KOSEKI Hironobu
    Department of Orthopedic Surgery, Graduate School of Biomedical Science, Nagasaki University
  • 志田 崇之
    Department of Orthopedic Surgery, Graduate School of Biomedical Science, Nagasaki University
  • 依田 周
    Department of Orthopedic Surgery, Graduate School of Biomedical Science, Nagasaki University
  • 堀内 英彦
    Department of Orthopedic Surgery, Graduate School of Biomedical Science, Nagasaki University
  • 尾﨑 誠
    Department of Orthopedic Surgery, Graduate School of Biomedical Science, Nagasaki University
  • 迫田 秀行
    国立医薬品食品衛生研究所　医療機器部

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  • 生体人工材料表面への表皮ブドウ球菌付着性の比較
  • セイタイ ジンコウ ザイリョウ ヒョウメン エ ノ ヒョウヒ ブドウ キュウキン フチャクセイ ノ ヒカク

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Abstract

Objective: The ability of bacteria to adhere to the surface of biomaterials is a pivotal event in the pathogenesis of implant-related infections. In this in vitro study, we evaluated the adherence ability of Staphylococcus epidermidis (S. epidermidis) (ATCC35984) to the surface of solid biomaterials, such as oxidized zirconium-niobium alloy (OXINIUM), cobalt-chrome alloy (CoCrMo), titanium alloy (Ti6Al4V), commercially pure titanium (cp-Ti), and stainless steel (SUS), respectively.<br>Methods: The surface roughness and wettability (water contact angles) of test specimens were analyzed, and viable adherent bacterial density was quantitatively determined (n = 10).<br>Results: Three-dimensional measuring via a laser microscope revealed featureless and smooth surfaces in all specimens (Ra < 10 nm). The mean value of S. epidermidis adherence to CoCrMo (9.7×105 cfu/ml) was significantly lower than that compared to Ti6Al4V (15.8×105 cfu/ml), cp-Ti (16.3×105 cfu/ml), or SUS (15.4×105 cfu/ml) (P < 0.05), respectively.<br>Conclusion: These results indicate that CoCrMo, which has a smooth and hydrophobic surface, is less susceptible to bacterial adherence and is less inclined to develop infection under a similar degree of roughness than the other materials.

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