Design of nanoparticulate drug delivery system for biofilm infection disease by spherical crystallization method

• Yamamoto Hiromitsu

  Department of Pharmaceutical Engineering, School of Pharmacy, Aichi-Gakuin University

• Ogawa Noriko

  Department of Pharmaceutical Engineering, School of Pharmacy, Aichi-Gakuin University

• Takahashi Chisato

  Department of Pharmaceutical Engineering, School of Pharmacy, Aichi-Gakuin University

Bibliographic Information

Other Title

• 球形晶析技術を応用したバイオフィルム感染症治療を目的としたナノ粒子製剤の開発
• キュウケイショウセキギジュツ オ オウヨウ シタ バイオフィルム カンセンショウ チリョウ オ モクテキ ト シタ ナノ リュウシ セイザイ ノ カイハツ

Abstract

Bacteria living in a biofilm can have significantly different properties from free-floating bacteria, as the dense and protected environment of the film allows them to cooperate and interact in various ways. This environment provides the resistance to detergents and antibiotics, as the dense extracellular matrix and the outer layer of cells protect the interior of the community. These biofilms cause the intractable infections. Therefore, the development of antibacterial drug delivery systems against the biofilm infection disease is strongly desired. In this review, we intended to design the surface modified PLGA nanoparticle and polymeric micelles for antibacterial drug delivery to the microorganisms in the biofilm. Clarithromycin-loaded drug carrier showed the stronger antibacterial effect against biofilm formed microorganisms compared with drug solution. Especially, CS-modified carrier indicated the more effective antibacterial activity and decreased the biofilm formation because nanocarrier adsorbed on the biofilm. Especially, soluplus micelles indicated the strongest anti-bacterial effect because the adsorption amount was higher than PLGA NP. Therefore, soluplus micelles with smaller particle size could access to the deeply part of biofilm which has sponge like structure.

Journal

• Drug Delivery System

  Drug Delivery System 30 (2), 129-138, 2015

  THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

Keywords

• Nanoparticle
• Spherical crystallization
• Biofilm infection disease

Details

• CRID: 1390282679617459584
• NII Article ID: 130005083739
• NII Article ID: 40020406599
• NII Book ID: AN10084591
• DOI: 10.2745/dds.30.129
• ISSN: 18812732
• ISSN: 09135006
• NDL BIB ID: 026271811
• Web Site: http://id.ndl.go.jp/bib/026271811
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I026271811
• Web Site: https://search.jamas.or.jp/link/ui/2015188360
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed