Complete Remission in Systemic Skin Interdigitating Dendritic Cell Sarcoma after ABVD Chemotherapy

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Author(s)

    • Kyogoku Chieko
    • Department of Hematology, Faculty of Medicine, University of Tsukuba
    • Hasegawa Yuichi
    • Department of Hematology, Faculty of Medicine, University of Tsukuba
    • Ichinohasama Ryo
    • Division of Hematopathology, Tohoku University Graduate School of Medicine
    • Nakamura Shigeo
    • Department of Pathology and Laboratory Medicine, Nagoya University Hospital
    • Chiba Shigeru
    • Department of Hematology, Faculty of Medicine, University of Tsukuba
    • Seki Masanori
    • Department of Hematology, Mito Medical Center, National Hospital Organization
    • Ogawa Shinichi
    • Department of Hematology, Faculty of Medicine, University of Tsukuba
    • Miyamoto Kana
    • Department of Hematology, Faculty of Medicine, University of Tsukuba
    • Ito Yufu
    • Department of Hematology, Faculty of Medicine, University of Tsukuba
    • Kurita Naoki
    • Department of Hematology, Faculty of Medicine, University of Tsukuba
    • Obara Naoshi
    • Department of Hematology, Faculty of Medicine, University of Tsukuba

Abstract

Interdigitating dendritic cell sarcoma (IDCS) is a rare and aggressive neoplasm that is thought to arise from dendritic cells. This disease usually involves the lymph nodes and, rarely, extra-nodal sites. We report a 62-year-old man presenting skin nodules in the head, body, and extremities, as well as bone marrow involvement. Morphologic analysis of a biopsied specimen from the skin lesion was consistent with IDCS. Immunohistochemical staining demonstrated that the tumor cells were positive for IDCS-associated antigens such as CD4, CD45, CD68 (KP-1), and S-100 protein. Complete remission was achieved by treatment with 6 cycles of ABVD (adriamycin, bleomycin, vinblastine, and dacarbazine) chemotherapy. Although the optimal treatment of IDSC remains unknown, the experience in the current case supports the notion that ABVD chemotherapy may be effective for IDCS, and further extends this idea to rare patients presenting multiple skin lesions.

Journal

  • Journal of Clinical and Experimental Hematopathology

    Journal of Clinical and Experimental Hematopathology 55(1), 33-37, 2015

    The Japanese Society for Lymphoreticular Tissue Research

Codes

  • NII Article ID (NAID)
    130005083796
  • Text Lang
    ENG
  • ISSN
    1346-4280
  • Data Source
    J-STAGE 
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