Proteinuria and Reduced Estimated Glomerular Filtration Rate Are Independent Risk Factors for Contrast-Induced Nephropathy After Cardiac Catheterization

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<b><i>Background:</i></b>The aim of this study was to investigate the incidence of contrast-induced nephropathy (CIN) according to renal function in patients with or without proteinuria after cardiac catheterization in Japan.<b><i>Methods and Results:</i></b>We conducted a multicenter prospective observational study involving 27 hospitals from all over Japan, which enrolled 906 patients with cardiac catheterization. CIN was defined as increase in serum creatinine ≥0.5 mg/dl or ≥25% from baseline between 48 and 72 h after exposure to contrast. The incidence of CIN in patients with estimated glomerular filtration rate (eGFR) <30 ml/min/1.73 m<sup>2</sup>was significantly higher than that in patients with eGFR ≥60 ml/min/1.73 m<sup>2</sup>. In patients without proteinuria, the incidence of CIN did not increase as eGFR decreased, but such a trend was observed in patients with proteinuria. Proteinuria was highly significantly associated with CIN in patients with eGFR 30–44 ml/min/1.73 m<sup>2</sup>(OR, 12.1; 95% CI: 2.81–82.8; P=0.0006) and eGFR <30 ml/min/1.73 m<sup>2</sup>(OR, 17.4; 95% CI: 3.32–321; P=0.0001). On multivariate logistic regression analysis, proteinuria (OR, 4.09; 95% CI: 1.66–10.0), eGFR (OR, 1.02; 95% CI: 1.00–1.04), contrast volume/eGFR (OR, 1.31; 95% CI: 1.04–1.65), and Ca antagonist use (OR, 3.79; 95% CI: 1.52–10.8) were significant predictors of CIN.<b><i>Conclusions:</i></b>Proteinuria and reduced eGFR are independent risk factors for CIN after cardiac catheterization. (<i>Circ J</i> 2015; <b>79:</b> 1624–1630)

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  • 日本循環器學誌

    日本循環器學誌 79(7), 1624-1630, 2015

    一般社団法人 日本循環器学会

各種コード

  • NII論文ID(NAID)
    130005083936
  • NII書誌ID(NCID)
    AA11591968
  • 本文言語コード
    ENG
  • ISSN
    1346-9843
  • NDL 記事登録ID
    026523808
  • NDL 請求記号
    Z54-B860
  • データ提供元
    NDL  J-STAGE 
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