Endoscopic examination of the fluorescence pattern of dysplasia after sensitization with 5-aminolevulinic acid in patients with chronic ulcerative colitis

• Iwasaki Tetsuyoshi

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine

• Kato Tomohiro

  Department of Endoscopy, The Jikei University School of Medicine

• Komoike Nobuhiko

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine

• Ide Daisuke

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine

• Mitobe Jimi

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine

• Mitsunaga Masato

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine

• Saruta Masayuki

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine

• Matsuoka Mika

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine

• Arihiro Seiji

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine

• Tajiri Hisao

  Division of Gastroenterology and Hepatology, Department of Internal Medicine, The Jikei University School of Medicine Department of Endoscopy, The Jikei University School of Medicine

Bibliographic Information

Other Title

• 潰瘍性大腸炎関連腫瘍の検出に対する，腫瘍親和性物質を用いた光線力学的診断

Abstract

In surveillance colonoscopy (SC) for patients with chronic ulcerative colitis (UC) , many endoscopic procedures have been performed, but reliable endoscopic detection methods still remain uncertain. Recently, photodynamic diagnosis (PDD) has been utilized clinically, especially in neurosurgical and urological procedures, to detect the extent of neoplasm. 5-Aminolevulinic acid (5-ALA) is converted intracellularly into the sensitizer protoporphyrin IX (PpIX) , which accumulates selectively in neoplastic tissue, allowing detection. As there are few reports regarding the use of 5-ALA for UC surveillance, its effectiveness and the 5-ALA-induced fluorescence pattern are still unclear. We previously reported the PpIX expression in dysplastic lesions, which was induced in a mouse model of colitis-associated cancer or dysplasia (CCD) . The aim of this study was to evaluate the fluorescence pattern after sensitization with 5-aminolevulinic acid (5-ALA) by using autofluorescence endoscopy (AFE) . Strong PpIX fluorescence signal was observed in both high- and low-grade dysplasia, especially at the margin of the low-grade dysplasia. AFE after 5-ALA sensitization offers the possibility of detecting CCD lesions by characteristic shape and color enhancement. Although the number of patients enrolled in this study was limited, our experience indicates that AFE is a promising method for detecting CCD lesions during UC surveillance.

Journal

• Progress of Digestive Endoscopy

  Progress of Digestive Endoscopy 86 (1), 83-86, 2015

  Japan Gastroenterological Endoscopy Society Kanto Chapter

Keywords

• ulcerative colitis
• colitic cancer or dysplasia (CCD)
• photodynamic diagnosis (PDD)

Details

• CRID: 1390001205439281152
• NII Article ID: 130005084328
• DOI: 10.11641/pde.86.1_83
• ISSN: 21874999
• ISSN: 13489844
• Web Site: https://search.jamas.or.jp/link/ui/2015318921
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed