Double Cold Trap Method to Determine the Concentrations of Volatile Organic Compounds in Human Expired Gas

• Nagaoka Takashi

  Department of Computational Systems Biology, Faculty of Biology-Oriented Science and Technology, Kinki University

• Kanou Saki

  Department of Electrical and Electronic Engineering, School of Engineering, Tokai University

• Kobayashi Naofumi

  Ogino Memorial Research Institute, Nihon Kohden Corporation

• Kurahashi Muneshige

  Ogino Memorial Research Institute, Nihon Kohden Corporation

• Oguma Tsuyoshi

  Division of Pulmonary Medicine, Department of Medicine, School of Medicine, Tokai University

• Tsuji Chizuko

  Division of Pulmonary Medicine, Department of Medicine, School of Medicine, Tokai University

• Aoki Takuya

  Division of Pulmonary Medicine, Department of Medicine, School of Medicine, Tokai University

• Urano Tetsuya

  Division of Pulmonary Medicine, Department of Medicine, School of Medicine, Tokai University

• Magatani Kazushige

  Department of Electrical and Electronic Engineering, School of Engineering, Tokai University

• Asano Koichiro

  Division of Pulmonary Medicine, Department of Medicine, School of Medicine, Tokai University

• Abe Tadashi

  Division of Pulmonary Medicine, Department of Medicine, School of Medicine, Tokai University

• Takeda Sunao

  Faculty of Science and Engineering, Waseda University

Abstract

Volatile organic compounds (VOCs) are organic chemical substances that volatilize easily in ambient air at normal temperature and pressure. VOCs in human expired gas have been reported to be useful in the diagnosis of various diseases, but measurement of VOCs in human expired gas is technically difficult because the concentrations in expired gas are extremely low and almost the same as the concentrations in ambient air. Accurate VOC measurement usually requires a large system, and no VOC measuring systems suitable for clinical practice are available. We developed a compact, simple, double cold trap system that can measure the concentrations of VOCs originating in humans. Our system detects a limited number of VOCs with very high sensitivity at concentrations as low as 0.05 ppb. We evaluated the reproducibility of our system and measured VOCs in ambient air, purified air, and human expired gas from smokers, non-smokers, and patients. Errors of ±10% seem unavoidable in our system. Our verification experiment using human expired gas strongly suggests that the reproducibility and detection sensitivity of our system allow the detection of most VOCs in human expired gas.

Journal

• Advanced Biomedical Engineering

  Advanced Biomedical Engineering 4 (0), 112-118, 2015

  Japanese Society for Medical and Biological Engineering

Keywords

• volatile organic compounds
• expired gas
• cold trap
• biomarker
• respiratory diseases

Details

• CRID: 1390282680480509952
• NII Article ID: 130005084357
• DOI: 10.14326/abe.4.112
• ISSN: 21875219
• Web Site: https://search.jamas.or.jp/link/ui/2017035167
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed