Diabetes Mellitus is Associated With Low Secretion Rates of Immunoglobulin A in Saliva

• Oikawa Junko

  Department of Public Health, Hokkaido University Graduate School of Medicine Department of Public Health, Chiba University Graduate School of Medicine

• Ukawa Shigekazu

  Department of Public Health, Hokkaido University Graduate School of Medicine

• Ohira Hideki

  Department of Psychology, Graduate School of Environmental Studies, Nagoya University

• Kawamura Takashi

  Kyoto University Health Service

• Wakai Kenji

  Department of Preventive Medicine, Nagoya University Graduate School of Medicine

• Ando Masahiko

  Center for Advanced Medicine and Clinical Research, Hospital, Nagoya University

• Hata Akira

  Department of Public Health, Chiba University Graduate School of Medicine

• Tamakoshi Akiko

  Department of Public Health, Hokkaido University Graduate School of Medicine

Abstract

Background: The association between diabetes mellitus (DM) and low secretory immunoglobulin A (s-IgA) secretion rates is one mechanism suspected of influencing susceptibility to infections among DM patients. However, several studies have shown contradictory results. We examined these two factors to seek evidence of an association among older people.<BR>Methods: We analyzed a prospective cohort of 2306 subjects (1209 men and 1097 women) around 64 years old from the New Integrated Suburban Seniority Investigation (NISSIN) Project in Nisshin, Japan. DM statuses were ascertained from levels of fasting plasma glucose and HbA_1c, and s-IgA secretion rates were obtained from 5-min saliva samples. We used an analysis of covariance adjusted for possible confounders to compare s-IgA secretion rates according to DM status.<BR>Results: s-IgA secretion rates in DM participants were lower than in those classified as normal (18.6 µg/min vs 15.0 µg/min, P = 0.03), even after elimination of the effects of possible confounders.<BR>Conclusions: DM was associated with lower s-IgA secretion rates. This suggests that lower s-IgA levels may be a mechanism of susceptibility to infection in individuals with DM.

Journal

• Journal of Epidemiology

  Journal of Epidemiology 25 (7), 470-474, 2015

  Japan Epidemiological Association

Keywords

• diabetes mellitus
• secretory immunoglobulin A
• saliva

Details

• CRID: 1390282679451841664
• NII Article ID: 120005647270
• NII Article ID: 130005086222
• DOI: 10.2188/jea.je20140088
• ISSN: 13499092
• ISSN: 09175040
• HANDLE: 2115/59746
• PubMed: 26094794
• Web Site: https://www.jstage.jst.go.jp/article/jea/advpub/0/advpub_JE20140088/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2016141666
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed