A Large-scale, Observational Study to Investigate the Current Status of Diabetic Complications and Their Prevention in Japan: Research Outline and Baseline Data for Type 1 Diabetes - JDCP study 2

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  • 糖尿病データベース構築委員会
  • Nishimura Rimei
    The Japan Diabetes Society Division of Diabetes, Metabolism & Endocrinology, Department of Internal Medicine, Jikei University School of Medicine
  • Izumi Kazuo
    The Japan Diabetes Society Japan Agency for Medical Research and Development
  • Hayashino Yasuaki
    The Japan Diabetes Society Tenri Hospital
  • Orikasa Hideki
    The Japan Diabetes Society Department of Biostatistics and Clinical Epidemiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama
  • Noda Mitsuhiko
    The Japan Diabetes Society The National Center for Global Health and Medicine
  • Ueki Kohjiro
    The Japan Diabetes Society Department of Molecular Science on Diabetes, Gracuate School of Medicine, The University of Tokyo
  • Tajima Naoko
    The Japan Diabetes Society Jikei University School of Medicine

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Other Title
  • 糖尿病合併症の実態とその抑制に関する大規模観察研究―1型糖尿病の登録時臨床像：JDCP study 2―
  • 委員会報告 糖尿病合併症の実態とその抑制に関する大規模観察研究 : 1型糖尿病の登録時臨床像 : JDCP study 2
  • イインカイ ホウコク トウニョウビョウ ガッペイショウ ノ ジッタイ ト ソノ ヨクセイ ニ カンスル ダイキボ カンサツ ケンキュウ : 1ガタ トウニョウビョウ ノ トウロクジ リンショウゾウ : JDCP study 2

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Abstract

The Japan Diabetes Complications and Prevention (JDCP) study is a prospective, large-scale observational study that was designed and conducted to investigate the current state of diabetes management among Japanese patients with type 1 and type 2 diabetes and its relationship with the occurrence of events detected during follow-up, thereby exploring the risk factors for the development and progression of diabetic complications. The study enrolled a total of 6,338 diabetes patients, who ranged from 40-75 years of age and who were treated in an outpatient setting between 2007 and 2009. The primary endpoint of the study was the occurrence of nephropathy, retinopathy, neuropathy, macroangiopathy or periodontal disease. The secondary endpoint was the occurrence of malignancy or mortality. Of the patients who were enrolled, those with type 1 diabetes (n=394) became the focus of this study. Their baseline clinical characteristics were examined. The men/women comprised 44.2 % and 55.8 % of the study population, respectively. Their baseline characteristics were as follows (men/women): mean age (55.3/56.8 years); duration of diabetes (11.9/11.1 years); percentage of patients with a family history of diabetes (22.7 %/35.6 %); BMI (22.4/21.8 kg/m2) (P=0.048); HbA1c (7.9 %/7.7 %); percentage of patients who achieved an HbA1c level of <7 % (23.1 %/26.9 %); systolic blood pressure (SBP) (126.0/124.9 mmHg); and LDL-C (106.1/107.7 mg/dL). The insulin therapy in place among the patients entailed 33.0±17.1 U of insulin as well as 0.58±0.25 U of insulin per 1 kg of body weight; 95.8 % of the patients performed self-monitoring of their blood glucose levels (SMBG).

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